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    浙江省科技型企業---加速您的多肽研究
    首頁 >多肽服務 >Bovine Adrenal Medulla (BAM) Peptides、牛腎上腺髓質肽

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    Bovine Adrenal Medulla (BAM) Peptides、牛腎上腺髓質肽
    • Bovine Adrenal Medulla (BAM) Peptides、牛腎上腺髓質多肽

      Definition

      Bovine adrenal medulla (BAM) peptides are peptides secreted in the adrenal gland that exhibit potent opioid activity1.

      Discovery

      BAM peptides were first purified from bovine adrenal medulla and it was found that upon their trypsinization they can yield the other enkephalin peptide-Met Enkephalin2. 

      Classification

      BAM peptides are cleavage products of the opioid peptide, pro-enkephalin. There are atleast three different BAM peptides that have been identified so far: BAM 12P, 20P and 22P3.

      Structural Characteristics

      BAM 22P is a docosa peptide that is a cleavage product of pro-enkephalin. BAM 20P and BAM 12P are C-terminal shortened versions of BAM 22P2.

      Mode of action

      BAM peptides normally bind to opioid receptors on neural cells and trigger a response.  For instance, BAM22P binds to G-Protein coupled sensory neuro receptors and opioid receptors which when activated trigger a series of pain signals4.

      Functions

      BAM peptides mainly expressed in the central nervous system have potent opioid activity. BAM22P inhibits reflex bladder action, induces analgesic response in mice and also exerts a protective action during stress such as shock or injury4. The exact functions of other BAM peptides remain unclear.

      References

      1. Swain MG, MacArthur L, Vergalla J and Jones EA (1994). Adrenal secretion of BAM-22P, a potent opioid peptide, is enhanced in rats with acute cholestasis. Am J Physiol Gastrointest Liver Physiol , 266, G201-G205.

      2. Mizuno K, Minamino N, Kangawa K and Matsuo H (1980). A new family of endogenous bigmet-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem. and Biophy. Res. Comm., 47, 1283-90.

      3. Book: Frank M and Klaus V, Molecular and Cellular Exercise Physiology.

      4. Yanguo H, Peifang D, Jianping J and Xueai Z (2004). Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent painpotential function of a novel receptor. Br J Pharmacol, 141(3): 423430.

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